Drug-induced aortitis in a patient with ovarian cancer treated with bevacizumab combination therapy

Objective: To review and evaluate drug-induced vasculitis, which is an extremely rare complication of chemotherapy. Case report: A 47-year-old woman with ovarian cancer developed aortitis during bevacizumab combination chemotherapy. Contract-enhanced CT showed concentric thickening of the descending...

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Bibliographic Details
Main Authors: Kengo Hiranuma, Soshi Kusunoki, Kazunari Fujino, Takashi Hirayama, Tsuyoshi Ota, Yasuhisa Terao
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Taiwanese Journal of Obstetrics & Gynecology
Online Access:http://www.sciencedirect.com/science/article/pii/S1028455918301931
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Summary:Objective: To review and evaluate drug-induced vasculitis, which is an extremely rare complication of chemotherapy. Case report: A 47-year-old woman with ovarian cancer developed aortitis during bevacizumab combination chemotherapy. Contract-enhanced CT showed concentric thickening of the descending aorta. Antibiotics were administered, but a repeat CE-CT scan showed no resolution of the aortitis. To treat the aortitis, she was started on oral prednisolone. A subsequent CE-CT scan showed no signs of aortitis. She was thus re-started on a modified chemotherapy regimen. Conclusion: Aortitis should be considered in patients receiving bevacizumab combination therapy who develop persistent fever and upper-abdominal pain. Contrast-enhanced CT is useful for detecting drug-induced aortitis. Keywords: Aortitis, Ovarian cancer, Bevacizumab, G-CSF
ISSN:1028-4559