Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model

Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model

Despite the use of ionizing radiation (IR) and temozolomide (TMZ), outcome for glioblastoma (GBM) patients remains dismal. Poly (ADP-ribose) polymerase (PARP) is important in repair pathways for IR-induced DNA damage and TMZ-induced alkylation at N7-methylguanine and N3-methyldenine. However, optimi...

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Bibliographic Details
Main Authors: Benjamin Lemasson, Hanxiao Wang, Stefanie Galbán, Yinghua Li, Yuan Zhu, Kevin A. Heist, Christina Tsein, Thomas L. Chenevert, Alnawaz Rehemtulla, Craig J. Galbán, Eric C. Holland, Brian D. Ross
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558615001694

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