Anti-Thyroid Peroxidase and Risk of Recurrent Spontaneous Abortion

• Main Authors: Mahnaz Ashrafi, Reza Salman Yazdi, Tahereh Madani, Alireza Bazrafshan
• Format: Article
• Language: English
• Published: Royan Institute (ACECR), Tehran 2007-09-01
• Series: International Journal of Fertility and Sterility
• Subjects: anti-thyroid peroxidase; recurrent spontaneous abortion
• Online Access: http://www.ijfs.ir/article_45654_d978613cff80d053ef4a3cc4d52ee261.pdf

Background Approximately 2-4% of all women have recurrent spontaneous abortion (RSA); however, the cause is determined in only 50% of cases. Recent studies have shown an association between thyroid autoantibodies as a sign of thyroid autoimmunity and abortion. The aim of the present study was to determine whether circulating anti-thyroid peroxidase (anti-TPO) was associated with RSA. Materials and methods In this observational analytic study, Sera from 58 non-pregnant women with a history of RSA and also 58 healthy, fertile subjects with at least one live birth as control (Aging from 18 to 45 years) were tested for thyroid peroxidase antibodies by means of a standard Anti-TPO ELISA kit. We used data collection forms and SPSS software for data analysis. Results Of 116 women, 8 (13.8%) of the control subjects and 12 (20.7%) of the women with a history of RSA had positive results for anti-TPO. There was not any significant association between presence of anti-TPO and RSA. Conclusion We did not find any correlation between the presence of TPO antibodies and abortion in women with a history of RSA. On the basis of this study, testing for anti-TPO doesn’t seem to be useful in the evaluation of patients with a history of RSA.