The role of apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease is doubtful.

The role of apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease is doubtful.

Machado-Joseph disease (MJD) is an inherited neurodegenerative disease caused by an expanded CAG repeat in the ATXN3 gene. Although the principal genetic determinant of the age at onset (AAO) is the length of the expanded CAG repeat, the additional genetic contribution of MJD toward the AAO has most...

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Bibliographic Details
Main Authors: Qi Zhou, Wang Ni, Yi Dong, Ning Wang, Shi-Rui Gan, Zhi-Ying Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4219713?pdf=render

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