Safety of sildenafil in premature infants with severe bronchopulmonary dysplasia (SILDI-SAFE): a multicenter, randomized, placebo-controlled, sequential dose-escalating, double-masked, safety study

Safety of sildenafil in premature infants with severe bronchopulmonary dysplasia (SILDI-SAFE): a multicenter, randomized, placebo-controlled, sequential dose-escalating, double-masked, safety study

Abstract Background Pulmonary hypertension is a deadly complication of bronchopulmonary dysplasia, the most common pulmonary morbidity of prematurity. Despite these catastrophic consequences, no evidence-based therapies are available for the prevention of pulmonary hypertension in this population. S...

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Bibliographic Details
Main Authors: Simone Schneider, Mary Bailey, Tracy Spears, Charles R. Esther, Matthew M. Laughon, Christoph P. Hornik, Wesley Jackson
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Pediatrics
Subjects:
Pulmonary hypertension
Premature infant
Bronchopulmonary dysplasia
Randomized control trial
Sildenafil
Hypotension
Online Access:https://doi.org/10.1186/s12887-020-02453-7

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