HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients

Rongrong Liu et al. find that Hantaan virus, a common cause of hemorrhagic fever with renal syndrome (HFRS) in China, can infect CD8+ T cells and that these cells can support the full viral replication cycle. They also see an association between CD8+ T cells infection and disease progression in HFRS...

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Main Authors:	Rongrong Liu, Ruixue Ma, Ziyu Liu, Haifeng Hu, Jiayi Shu, Peizhen Hu, Junjun Kang, Yusi Zhang, Mingwei Han, Xiaoxiao Zhang, Yiting Zheng, Qikang Ying, Shiyuan Hou, Wenqiu Wang, Fang Wang, Ning Cheng, Yan Zhuang, Jianqi Lian, Xia Jin, Xingan Wu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-02182-2

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spelling	doaj-5bc584b61789445782cbe26f90784bc12021-06-06T11:30:39ZengNature Publishing GroupCommunications Biology2399-36422021-06-014111010.1038/s42003-021-02182-2HTNV infection of CD8+ T cells is associated with disease progression in HFRS patientsRongrong Liu0Ruixue Ma1Ziyu Liu2Haifeng Hu3Jiayi Shu4Peizhen Hu5Junjun Kang6Yusi Zhang7Mingwei Han8Xiaoxiao Zhang9Yiting Zheng10Qikang Ying11Shiyuan Hou12Wenqiu Wang13Fang Wang14Ning Cheng15Yan Zhuang16Jianqi Lian17Xia Jin18Xingan Wu19Department of Microbiology, School of Basic Medicine, Fourth Military Medical UniversityDepartment of Microbiology, School of Basic Medicine, Fourth Military Medical UniversityDepartment of Microbiology, School of Basic Medicine, Fourth Military Medical UniversityDepartment of Infective Diseases, Tangdu Hospital, Fourth Military Medical UniversityShanghai Public Health Clinical Center, Fudan UniversityState Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical UniversitySchool of Basic Medicine, Fourth Military Medical UniversitySchool of Basic Medicine, Fourth Military Medical UniversitySchool of Basic Medicine, Fourth Military Medical UniversityDepartment of Microbiology, School of Basic Medicine, Fourth Military Medical UniversitySchool of Basic Medicine, Fourth Military Medical UniversityDepartment of Microbiology, School of Basic Medicine, Fourth Military Medical UniversityDepartment of Microbiology, School of Basic Medicine, Fourth Military Medical UniversitySchool of Basic Medicine, Fourth Military Medical UniversityDepartment of Microbiology, School of Basic Medicine, Fourth Military Medical UniversityDepartment of Otolaryngology-Head and Neck Surgery, University of CaliforniaDepartment of Infective Diseases, Tangdu Hospital, Fourth Military Medical UniversityDepartment of Infective Diseases, Tangdu Hospital, Fourth Military Medical UniversityShanghai Public Health Clinical Center, Fudan UniversityDepartment of Microbiology, School of Basic Medicine, Fourth Military Medical UniversityRongrong Liu et al. find that Hantaan virus, a common cause of hemorrhagic fever with renal syndrome (HFRS) in China, can infect CD8+ T cells and that these cells can support the full viral replication cycle. They also see an association between CD8+ T cells infection and disease progression in HFRS patients.https://doi.org/10.1038/s42003-021-02182-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rongrong Liu Ruixue Ma Ziyu Liu Haifeng Hu Jiayi Shu Peizhen Hu Junjun Kang Yusi Zhang Mingwei Han Xiaoxiao Zhang Yiting Zheng Qikang Ying Shiyuan Hou Wenqiu Wang Fang Wang Ning Cheng Yan Zhuang Jianqi Lian Xia Jin Xingan Wu
spellingShingle	Rongrong Liu Ruixue Ma Ziyu Liu Haifeng Hu Jiayi Shu Peizhen Hu Junjun Kang Yusi Zhang Mingwei Han Xiaoxiao Zhang Yiting Zheng Qikang Ying Shiyuan Hou Wenqiu Wang Fang Wang Ning Cheng Yan Zhuang Jianqi Lian Xia Jin Xingan Wu HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients Communications Biology
author_facet	Rongrong Liu Ruixue Ma Ziyu Liu Haifeng Hu Jiayi Shu Peizhen Hu Junjun Kang Yusi Zhang Mingwei Han Xiaoxiao Zhang Yiting Zheng Qikang Ying Shiyuan Hou Wenqiu Wang Fang Wang Ning Cheng Yan Zhuang Jianqi Lian Xia Jin Xingan Wu
author_sort	Rongrong Liu
title	HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients
title_short	HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients
title_full	HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients
title_fullStr	HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients
title_full_unstemmed	HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients
title_sort	htnv infection of cd8+ t cells is associated with disease progression in hfrs patients
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-06-01
description	Rongrong Liu et al. find that Hantaan virus, a common cause of hemorrhagic fever with renal syndrome (HFRS) in China, can infect CD8+ T cells and that these cells can support the full viral replication cycle. They also see an association between CD8+ T cells infection and disease progression in HFRS patients.
url	https://doi.org/10.1038/s42003-021-02182-2
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HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients

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