HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients

Rongrong Liu et al. find that Hantaan virus, a common cause of hemorrhagic fever with renal syndrome (HFRS) in China, can infect CD8+ T cells and that these cells can support the full viral replication cycle. They also see an association between CD8+ T cells infection and disease progression in HFRS...

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Bibliographic Details
Main Authors: Rongrong Liu, Ruixue Ma, Ziyu Liu, Haifeng Hu, Jiayi Shu, Peizhen Hu, Junjun Kang, Yusi Zhang, Mingwei Han, Xiaoxiao Zhang, Yiting Zheng, Qikang Ying, Shiyuan Hou, Wenqiu Wang, Fang Wang, Ning Cheng, Yan Zhuang, Jianqi Lian, Xia Jin, Xingan Wu
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02182-2
Description
Summary:Rongrong Liu et al. find that Hantaan virus, a common cause of hemorrhagic fever with renal syndrome (HFRS) in China, can infect CD8+ T cells and that these cells can support the full viral replication cycle. They also see an association between CD8+ T cells infection and disease progression in HFRS patients.
ISSN:2399-3642