Advances in SPECT for Optimizing the Liver Tumors Radioembolization Using Yttrium-90 Microspheres

• Main Authors: Hoda Rezaei Roshan, Ahmadreza Azarm, Babak Mahmoudian, Jalil Pirayesh Islamian
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2015-01-01
• Series: World Journal of Nuclear Medicine
• Subjects: Bremsstrahlung SPECT; radioembolization; single photon emission computed tomography/computed tomography; Yttrium-90 microspheres
• Online Access: http://www.wjnm.org/article.asp?issn=1450-1147;year=2015;volume=14;issue=2;spage=75;epage=80;aulast=Roshan
• ISSN: 1450-1147

Radioembolization (RE) with Yttrium-90 ( 90 Y) microspheres is an effective treatment for unresectable liver tumors. The activity of the microspheres to be administered should be calculated based on the type of microspheres. Technetium-99m macroaggregated albumin ( 99m Tc-MAA) single photon emission computed tomography/computed tomography (SPECT/CT) is a reliable assessment before RE to ensure the safe delivery of microspheres into the target. 90 Y bremsstrahlung SPECT imaging as a posttherapeutic assessment approach enables the reliable determination of absorbed dose, which is indispensable for the verification of treatment efficacy. This article intends to provide a review of the methods of optimizing 90 Y bremsstrahlung SPECT imaging to improve the treatment efficacy of liver tumor RE using 90 Y microspheres.