Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone–Vascular Axis

Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone–Vascular Axis

Sclerostin is a well-known inhibitor of bone formation that acts on Wnt/β-catenin signaling. This manuscript considers the possible role of sclerostin in vascular calcification, a process that shares many similarities with physiological bone formation. Rats were exposed to a warfarin-contai...

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Bibliographic Details
Main Authors: Annelies De Maré, Stuart Maudsley, Abdelkrim Azmi, Jhana O. Hendrickx, Britt Opdebeeck, Ellen Neven, Patrick C D’Haese, Anja Verhulst
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Toxins
Subjects:
chronic kidney disease
vascular calcification
bone disease
mineral abnormalities
rat model
Online Access:https://www.mdpi.com/2072-6651/11/7/428

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