Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16–64 years in Puerto Rico

Background: To understand risk factors for HPV exposure in Puerto Rican women, we evaluated HPV 6, 11, 16, and 18 serology in women aged living in the San Juan metropolitan area. Methods: As part of a cross-sectional study, a population-based sample of 524 HPV unvaccinated Hispanic women ages 16–64...

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Main Authors: A.P. Ortiz, G. Tortolero-Luna, J. Romaguera, C.M. Pérez, D. González, C. Muñoz, L. González, E. Marrero, E. Suárez, J.M. Palefsky, G. Panicker, E.R. Unger
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Papillomavirus Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2405852117300769
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spelling doaj-5bb40573f36b40fa9ec2adc94f57266e2020-11-25T01:07:19ZengElsevierPapillomavirus Research2405-85212018-06-015109113Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16–64 years in Puerto RicoA.P. Ortiz0G. Tortolero-Luna1J. Romaguera2C.M. Pérez3D. González4C. Muñoz5L. González6E. Marrero7E. Suárez8J.M. Palefsky9G. Panicker10E.R. Unger11Cancer Control and Population Sciences Program, Comprehensive Cancer Center, University of Puerto Rico, USA; Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, USA; Corresponding author at: University of Puerto Rico Comprehensive Cancer Center, PO Box 363027, San Juan, PR 00936-3027, USA.Cancer Control and Population Sciences Program, Comprehensive Cancer Center, University of Puerto Rico, USADepartment of OBGYN, School of Medicine, Medical Sciences Campus, University of Puerto Rico, USADepartment of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, USADepartment of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, USACancer Control and Population Sciences Program, Comprehensive Cancer Center, University of Puerto Rico, USAPuerto Rico Clinical and Translational Research Consortium, Medical Sciences Campus, University of Puerto Rico, USACancer Control and Population Sciences Program, Comprehensive Cancer Center, University of Puerto Rico, USADepartment of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico, USAUniversity of California, San Francisco (UCSF), USADivision of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USADivision of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USABackground: To understand risk factors for HPV exposure in Puerto Rican women, we evaluated HPV 6, 11, 16, and 18 serology in women aged living in the San Juan metropolitan area. Methods: As part of a cross-sectional study, a population-based sample of 524 HPV unvaccinated Hispanic women ages 16–64 years completed face-to-face and computer assisted interviews and provided blood and self-collected anal and cervical specimens. Serology used multiplex virus-like particle based-IgG ELISA and HPV DNA was detected with L1-consensus PCR. Results: 32% and 47% were seropositive to HPV types included in the bivalent (16/18) and quadrivalent (6/11/16/18) vaccines, respectively. Type-specific seroprevalence was HPV6 − 29%, HPV11 − 18%, HPV16 − 23%, and HPV18 − 17%; seroprevalence was high in the youngest age-group (16–19: 26–37%). HPV seropositivity was associated with having ≥ 3 lifetime sexual partners (OR=2.5, 95% CI=1.7–3.9) and detection of anogenital HPV DNA (OR=1.8, 95% CI=1.2–2.6). Conclusions: The high cumulative exposure of HPV vaccine types 6/11/16/18 in this Hispanic population was influenced by factors related to HPV exposure through sexual behavior. High seroprevalence in the youngest age-group indicates early age of exposure to HPV in Puerto Rico, highlighting the need for HPV vaccination starting prior to age 16.http://www.sciencedirect.com/science/article/pii/S2405852117300769
collection DOAJ
language English
format Article
sources DOAJ
author A.P. Ortiz
G. Tortolero-Luna
J. Romaguera
C.M. Pérez
D. González
C. Muñoz
L. González
E. Marrero
E. Suárez
J.M. Palefsky
G. Panicker
E.R. Unger
spellingShingle A.P. Ortiz
G. Tortolero-Luna
J. Romaguera
C.M. Pérez
D. González
C. Muñoz
L. González
E. Marrero
E. Suárez
J.M. Palefsky
G. Panicker
E.R. Unger
Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16–64 years in Puerto Rico
Papillomavirus Research
author_facet A.P. Ortiz
G. Tortolero-Luna
J. Romaguera
C.M. Pérez
D. González
C. Muñoz
L. González
E. Marrero
E. Suárez
J.M. Palefsky
G. Panicker
E.R. Unger
author_sort A.P. Ortiz
title Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16–64 years in Puerto Rico
title_short Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16–64 years in Puerto Rico
title_full Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16–64 years in Puerto Rico
title_fullStr Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16–64 years in Puerto Rico
title_full_unstemmed Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16–64 years in Puerto Rico
title_sort seroprevalence of hpv 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16–64 years in puerto rico
publisher Elsevier
series Papillomavirus Research
issn 2405-8521
publishDate 2018-06-01
description Background: To understand risk factors for HPV exposure in Puerto Rican women, we evaluated HPV 6, 11, 16, and 18 serology in women aged living in the San Juan metropolitan area. Methods: As part of a cross-sectional study, a population-based sample of 524 HPV unvaccinated Hispanic women ages 16–64 years completed face-to-face and computer assisted interviews and provided blood and self-collected anal and cervical specimens. Serology used multiplex virus-like particle based-IgG ELISA and HPV DNA was detected with L1-consensus PCR. Results: 32% and 47% were seropositive to HPV types included in the bivalent (16/18) and quadrivalent (6/11/16/18) vaccines, respectively. Type-specific seroprevalence was HPV6 − 29%, HPV11 − 18%, HPV16 − 23%, and HPV18 − 17%; seroprevalence was high in the youngest age-group (16–19: 26–37%). HPV seropositivity was associated with having ≥ 3 lifetime sexual partners (OR=2.5, 95% CI=1.7–3.9) and detection of anogenital HPV DNA (OR=1.8, 95% CI=1.2–2.6). Conclusions: The high cumulative exposure of HPV vaccine types 6/11/16/18 in this Hispanic population was influenced by factors related to HPV exposure through sexual behavior. High seroprevalence in the youngest age-group indicates early age of exposure to HPV in Puerto Rico, highlighting the need for HPV vaccination starting prior to age 16.
url http://www.sciencedirect.com/science/article/pii/S2405852117300769
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