Nodal Facilitates Differentiation of Fibroblasts to Cancer-Associated Fibroblasts that Support Tumor Growth in Melanoma and Colorectal Cancer

Nodal Facilitates Differentiation of Fibroblasts to Cancer-Associated Fibroblasts that Support Tumor Growth in Melanoma and Colorectal Cancer

Fibroblasts become cancer-associated fibroblasts (CAFs) in the tumor microenvironment after activation by transforming growth factor-β (TGF-β) and are critically involved in cancer progression. However, it is unknown whether the TGF superfamily member Nodal, which is expressed in v...

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Bibliographic Details
Main Authors: Ziqian Li, Junjie Zhang, Jiawang Zhou, Linlin Lu, Hongsheng Wang, Ge Zhang, Guohui Wan, Shaohui Cai, Jun Du
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
Nodal
CAFs
differentiation
tumor growth
melanoma
colorectal cancer
Online Access:https://www.mdpi.com/2073-4409/8/6/538

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