Functionalized azetidines via visible light-enabled aza Paternò-Büchi reactions

Functionalized azetidines via visible light-enabled aza Paternò-Büchi reactions

The Aza Paternò-Büchi reaction is arguably among the most direct approaches to functionalized azetidines, which are common medicinal scaffolds. Here, the authors report a mild and selective visible light-enabled intramolecular aza Paternò-Büchi reaction yielding bicyclic azetidines in high yields an...

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Main Authors: Marc R. Becker, Alistair D. Richardson, Corinna S. Schindler
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13072-x
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spelling doaj-5b94bd99ca7649488389d44b9b8bbe692021-05-11T12:24:48ZengNature Publishing GroupNature Communications2041-17232019-11-011011810.1038/s41467-019-13072-xFunctionalized azetidines via visible light-enabled aza Paternò-Büchi reactionsMarc R. Becker0Alistair D. Richardson1Corinna S. Schindler2Willard Henry Dow Laboratory, Department of Chemistry, University of MichiganWillard Henry Dow Laboratory, Department of Chemistry, University of MichiganWillard Henry Dow Laboratory, Department of Chemistry, University of MichiganThe Aza Paternò-Büchi reaction is arguably among the most direct approaches to functionalized azetidines, which are common medicinal scaffolds. Here, the authors report a mild and selective visible light-enabled intramolecular aza Paternò-Büchi reaction yielding bicyclic azetidines in high yields and diastereoselectivity.https://doi.org/10.1038/s41467-019-13072-x
collection DOAJ
language English
format Article
sources DOAJ
author Marc R. Becker
Alistair D. Richardson
Corinna S. Schindler
spellingShingle Marc R. Becker
Alistair D. Richardson
Corinna S. Schindler
Functionalized azetidines via visible light-enabled aza Paternò-Büchi reactions
Nature Communications
author_facet Marc R. Becker
Alistair D. Richardson
Corinna S. Schindler
author_sort Marc R. Becker
title Functionalized azetidines via visible light-enabled aza Paternò-Büchi reactions
title_short Functionalized azetidines via visible light-enabled aza Paternò-Büchi reactions
title_full Functionalized azetidines via visible light-enabled aza Paternò-Büchi reactions
title_fullStr Functionalized azetidines via visible light-enabled aza Paternò-Büchi reactions
title_full_unstemmed Functionalized azetidines via visible light-enabled aza Paternò-Büchi reactions
title_sort functionalized azetidines via visible light-enabled aza paternò-büchi reactions
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-11-01
description The Aza Paternò-Büchi reaction is arguably among the most direct approaches to functionalized azetidines, which are common medicinal scaffolds. Here, the authors report a mild and selective visible light-enabled intramolecular aza Paternò-Büchi reaction yielding bicyclic azetidines in high yields and diastereoselectivity.
url https://doi.org/10.1038/s41467-019-13072-x
work_keys_str_mv AT marcrbecker functionalizedazetidinesviavisiblelightenabledazapaternobuchireactions
AT alistairdrichardson functionalizedazetidinesviavisiblelightenabledazapaternobuchireactions
AT corinnasschindler functionalizedazetidinesviavisiblelightenabledazapaternobuchireactions
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