Prebiotic Mannan Oligosaccharide Pretreatment Improves Mice Survival Against Lethal Effects of Gamma Radiation by Protecting GI Tract and Hematopoietic Systems

Prebiotic Mannan Oligosaccharide Pretreatment Improves Mice Survival Against Lethal Effects of Gamma Radiation by Protecting GI Tract and Hematopoietic Systems

Total body irradiation (TBI) results in critical injuries in a dose dependent manner that primarily damages highly proliferating tissues including hematopoietic stem cells (HSCs) and intestinal crypt stem cells etc. This may result in hematopoietic syndrome leading to bone marrow failure and gastroi...

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Bibliographic Details
Main Authors: Sweta Sanguri, Damodar Gupta
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
total body irradiation
gastrointestinal syndrome
hematopoietic syndrome
radiation countermeasure agents
mannan oligosaccharide
prebiotics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.677781/full

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