Cytotoxic Marine Alkaloid 3,10-Dibromofascaplysin Induces Apoptosis and Synergizes with Cytarabine Resulting in Leukemia Cell Death

Cytotoxic Marine Alkaloid 3,10-Dibromofascaplysin Induces Apoptosis and Synergizes with Cytarabine Resulting in Leukemia Cell Death

Myeloid leukemia is a hematologic neoplasia characterized by a clonal proliferation of hematopoietic stem cell progenitors. Patient prognosis varies depending on the subtype of leukemia as well as eligibility for intensive treatment regimens and allogeneic stem cell transplantation. Although signifi...

Full description

Bibliographic Details
Main Authors: Pavel Spirin, Elena Shyrokova, Timofey Lebedev, Elmira Vagapova, Polina Smirnova, Alexey Kantemirov, Sergey A. Dyshlovoy, Gunhild von Amsberg, Maxim Zhidkov, Vladimir Prassolov
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Marine Drugs
Subjects:
leukemia
fascaplysin
E2F1
apoptosis
synergism
Online Access:https://www.mdpi.com/1660-3397/19/9/489

Internet

https://www.mdpi.com/1660-3397/19/9/489

Similar Items