RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination

RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination

Abstract Background Patients with lung adenocarcinoma (LUAD) have high mortality rate and poor prognosis. The LUAD cells display increased aerobic glycolysis, which generates energy required for their survival and proliferation. Deregulation of Wnt/β-catenin signaling pathway induces the metabolism...

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Bibliographic Details
Main Authors: Xiao-Ting Wu, Yu-Han Wang, Xiao-Yue Cai, Yun Dong, Qing Cui, Ya-Ning Zhou, Xi-Wen Yang, Wen-Feng Lu, Ming Zhang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer & Metabolism
Subjects:
Cell proliferation
Glycolysis
Apoptosis
Wnt pathway
Ubiquitination
Online Access:https://doi.org/10.1186/s40170-021-00243-y

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