A Humanized Anti-GPC3 Antibody for Immuno-Positron Emission Tomography Imaging of Orthotopic Mouse Model of Patient-Derived Hepatocellular Carcinoma Xenografts

A Humanized Anti-GPC3 Antibody for Immuno-Positron Emission Tomography Imaging of Orthotopic Mouse Model of Patient-Derived Hepatocellular Carcinoma Xenografts

Glypican-3 (GPC3) is an attractive diagnostic marker for hepatocellular carcinoma (HCC). We previously reported the potential of an <sup>89</sup>Zr-labeled murine anti-GPC3 antibody (clone 1G12) for immunoPET imaging of HCC in orthotopic patient-derived xenograft (PDX) mouse models. We n...

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Bibliographic Details
Main Authors: Arutselvan Natarajan, Hui Zhang, Wei Ye, Lakshmi Huttad, Mingdian Tan, Mei-Sze Chua, Sanjiv S. Gambhir, Samuel K. So
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
immunoPET imaging
humanized antibody
glypican-3
hepatocellular carcinoma
Online Access:https://www.mdpi.com/2072-6694/13/16/3977

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