A Unique Anti-Cancer 3-Styrylchromone Suppresses Inflammatory Response via HMGB1-RAGE Signaling

A Unique Anti-Cancer 3-Styrylchromone Suppresses Inflammatory Response via HMGB1-RAGE Signaling

High mobility group box 1 (HMGB1)-receptor for advanced glycation endo-products (RAGE) axis serves as a key player in linking inflammation and carcinogenesis. Recently, papaverine was revealed to suppress the HMGB1-RAGE inflammatory signaling pathway and cancer cell proliferation. Therefore, a dual...

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Bibliographic Details
Main Authors: Hideaki Abe, Miwa Okazawa, Takahiro Oyama, Hiroaki Yamazaki, Atsushi Yoshimori, Takanori Kamiya, Mitsutoshi Tsukimoto, Koichi Takao, Yoshiaki Sugita, Hiroshi Sakagami, Takehiko Abe, Sei-ichi Tanuma
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Medicines
Subjects:
inflammation
tumor microenvironment
carcinogenesis
RAGE
HMGB1
ERK 1/2
Online Access:https://www.mdpi.com/2305-6320/8/4/17

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