PSMA-Oriented Target Delivery of Novel Anticancer Prodrugs: Design, Synthesis, and Biological Evaluations of Oligopeptide-Camptothecin Conjugates

PSMA-Oriented Target Delivery of Novel Anticancer Prodrugs: Design, Synthesis, and Biological Evaluations of Oligopeptide-Camptothecin Conjugates

Clinical applications of camptothecin (CPT) have been heavily hindered due to its non-targeted toxicity, active lactone ring instability, and poor water solubility. Targeted drug delivery systems may offer the possibility to overcome the above issues as reported. In this research, a series of prosta...

Full description

Bibliographic Details
Main Authors: Bing Xu, Fei Zhou, Meng-Meng Yan, De-Sheng Cai, Wen-Bo Guo, Yu-Qin Yang, Xiao-Hui Jia, Wen-Xi Zhang, Tong Li, Tao Ma, Peng-Long Wang, Hai-Min Lei
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
camptothecin
oligopeptide derivatives
prostate-specific membrane antigen
structure-activity relationships
apoptosis
Online Access:http://www.mdpi.com/1422-0067/19/10/3251

Internet

http://www.mdpi.com/1422-0067/19/10/3251

Similar Items