Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.

Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.

BACKGROUND & AIMS:The interferon (IFN) system plays a critical role in innate antiviral response. We presume that targeted induction of IFN in human liver shows robust antiviral effects on hepatitis C virus (HCV) and hepatitis B virus (HBV). METHODS:This study used chimeric mice harboring humani...

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Bibliographic Details
Main Authors: Shin-ichiro Nakagawa, Yuichi Hirata, Takeshi Kameyama, Yuko Tokunaga, Yasumasa Nishito, Kazuko Hirabayashi, Junichi Yano, Takahiro Ochiya, Chise Tateno, Yasuhito Tanaka, Masashi Mizokami, Kyoko Tsukiyama-Kohara, Kazuaki Inoue, Makoto Yoshiba, Akinori Takaoka, Michinori Kohara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3610702?pdf=render

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http://europepmc.org/articles/PMC3610702?pdf=render

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