Rapid multi-directed cholinergic transmission in the central nervous system

Cholinergic neurons may transmit information via fast synaptic, point-to-point signaling or diffuse, slow extra-synaptic signaling. The authors show that ACh from a single vesicle triggers synchronous miniature currents in two neurons, showing that ACh can spread significant distances to drive rapid...

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Bibliographic Details
Main Authors: Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin Murphy-Baum, J Michael McIntosh, Miao Jing, Yulong Li, David Berson, Keisuke Yonehara, Gautam B. Awatramani
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21680-9