Engineering Nano-aggregates: β-Cyclodextrin Facilitates the Thiol-Gold Nanoparticle Self-Assembly

• Main Authors: D Badmapriya, Sameena Yousuf, Israel Enoch
• Format: Article
• Language: English
• Published: Nanoscience and Nanotechnology Research Center, University of Kashan 2019-10-01
• Series: Journal of Nanostructures
• Subjects: gold nanoparticles; self-assembly; oxadiazole; host-guest complex
• Online Access: http://jns.kashanu.ac.ir/article_99380_7850cba96eb8e33563a0b3228292dbda.pdf
• ISSN: 2251-7871; 2251-788X

The structure and morphology of nonmaterial formed by colloidal synthesis represent a subject of interest as it is a factor deciding the physicochemical properties and biological applications of nanostructures. Among various nanoparticles, gold can develop fractal assembled patterns. Herein, we report a nano-aggregate of a thiol-on-gold self-assembled structure and the influence of β-cyclodextrin on the self-assembly. The host: guest association of the 5-(4-pyridyl)-1,3,4-oxadiazole-2-thiol is studied using UV-visible, fluorescence spectroscopy and molecular modelling analysis. In free form unbound to gold nanoparticles, the thiol compound forms a cyclodextrin complex with a 1: 1 stoichiometry. The thiol assembled on gold nanoparticles, aggregating to constitute irregular patterns. β-cyclodextrin encapsulates the thiol-on-gold nanoparticles and their morphology changes. The influence of β-cyclodextrin on the aggregation of the thiol guest molecule and the morphology of the thiol-on-gold nanostructure is discussed. The non-covalent complex made up by the thiol molecule with cyclodextrin plays a vital role in tuning the structure of the nanostructure when assembled on gold nanoparticles.The study will open up a significant method in the approach towards site specific drug delivery via a physical encapsulation.