The Beta Lactam Antibiotics as an Empirical Therapy in a Developing Country: An Update on Their Current Status and Recommendations to Counter the Resistance against Them
In a developing country like India, where the patients have to bear the cost of their healthcare, the microbiological culture and the sensitivity testing of each and every infection is not feasible. Moreover, there are lacunae in the data storage, management and the sharing of knowledge with res...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3052/61%20-%205239_PF1(M)_E(C)_F(T)_PF1(M)_PF1(T)_PF1(PUH)_PFA(PUH).pdf |
| Summary: | In a developing country like India, where the patients have to
bear the cost of their healthcare, the microbiological culture and
the sensitivity testing of each and every infection is not feasible.
Moreover, there are lacunae in the data storage, management
and the sharing of knowledge with respect to the microorganisms
which are prevalent in the local geographical area and with
respect to the antibiotics which are effective against them. Thus,
an empirical therapy for treating infections is imperative in such
a setting. The beta lactam antibiotics have been widely used for
the empirical treatment of infections since the the discovery of
penicillin. Many generations of beta lactams have been launched
with, the claims of a higher sensitivity and less resistance, but
their sensitivity has drastically decreased over time. Thus, the
preference for beta lactams, especially the cephalosporins, as
an empirical therapy, among the prescribers was justified initially,
but the current sensitivity patterns do not support their empirical
use in hospital and community acquired infections. There is a
need for increasing the awareness and the attitudinal change
among the prescribers, screening of the antibiotic prescriptions,
the strict implementation of antibiotic policies in hospital settings,
restricting the hospital supplies and avoiding the prescriptions
of beta lactams, a regular census of the local sensitivity patterns
to formulate and update the antibiotic policies, upgradation of
the laboratory facilities for a better and faster detection of the
isolates, proper collection, analyses and sharing of the data and
the encouragement of the research and development of newer
antibiotics with novel mechanisms of action. |
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| ISSN: | 2249-782X 0973-709X |