Radiation- and Photo-induced Activation of 5-Fluorouracil Prodrugs as a Strategy for the Selective Treatment of Solid Tumors

Radiation- and Photo-induced Activation of 5-Fluorouracil Prodrugs as a Strategy for the Selective Treatment of Solid Tumors

5-Fluorouracil (5-FU) is used widely as an anticancer drug to treat solid cancers, such as colon, breast, rectal, and pancreatic cancers, although its clinical application is limited because 5-FU has gastrointestinal and hematological toxicity. Many groups are searching for prodrugs with functions t...

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Bibliographic Details
Main Authors: Sei-ichi Nishimoto, Hiroshi Hatta, Hisatsugu Yamada, Kazuhito Tanabe, Takeo Ito
Format: Article
Language:English
Published: MDPI AG 2008-10-01
Series:Molecules
Subjects:
5-Fluorouracil
Prodrugs
Hypoxia
Hydrated Electrons
Radiolysis
Photolysis
Online Access:http://www.mdpi.com/1420-3049/13/10/2370/

Internet

http://www.mdpi.com/1420-3049/13/10/2370/

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