Micronuclei Frequencies and Nuclear Abnormalities in Oral Exfoliated Cells of Nuclear Power Plant Workers

• Main Authors: Shitalkumar G Sagari, Roopa Babannavar, Abhishek Lohra, Ashwin Kodgi, Sunil Bapure, Yogesh Rao, Arun J., Manjunath Malghan
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2014-12-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: dna damage; exfoliative cytology; genotoxicity; micronucleus
• Online Access: https://jcdr.net/articles/PDF/5240/9059_CE(Ra)_F(Sh)_PF1(PAK)_PFA(Sh)_PFA2(AK).pdf

Aim: Biomonitoring provides a useful tool to estimate the genetic risk from exposure to genotoxic agents. The aim of this study was to evaluate the frequencies of Micronuclei (MN) and other Nuclear abnormalities (NA) from exfoliated oral mucosal cells in Nuclear Power Station (NPS) workers. Materials and Methods: Micronucleus frequencies in oral exfoliated cells were done from individuals not known to be exposed to either environmental or occupational carcinogens (Group I). Similarly samples were obtained from full-time Nuclear Power Station (NPS) workers with absence of Leukemia and any malignancy (Group II) and workers diagnosed as leukemic patients and undergoing treatment (Group III). Results: There was statistically significant difference between Group I, Group II & Group III. MN and NA frequencies in Leukemic Patients were significantly higher than those in exposed workers &control groups (p < 0.05). Conclusion: MN and other NA reflect genetic changes, events associated with malignancies. Therefore, there is a need to educate those who work in NPS about the potential hazard of occupational exposure and the importance of using protective measures.