The effect of high intencity interval training combined with curcumin supplementation on Plasma glucose concentration and insulin resistance in diabetic rats

• Main Authors: Ali Akbarzadeh, Abbas Fattahi bafghi
• Format: Article
• Language: fas
• Published: Shahid Sadoughi University of Medical Sciences 2018-03-01
• Series: Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
• Subjects: high intensity interval training; curcumin supplement; Plasma glucose; insulin resistance
• Online Access: http://jssu.ssu.ac.ir/browse.php?a_code=A-10-3321-1&slc_lang=en&sid=1

Introduction: Diabetes mellitus is a common condition that is recommended for the treatment and control of various therapies, such as the use of natural drugs and inactivity reduction.It has been reported exercise and herbs can possess synergistic effects to control diabetes side-effects. The purpose of the present study was investigation of the effects of high-intensity interval training and taking curcumin supplement on Concentration of glucose and insulin resistance, in diabetic rats. Methods: In a clinical trial Thirty-two male Wistar rats were randomly divided to four groups of curcumin, training, training- curcumin, and control. The subjects had being trained to perform high-intensity interval training on treadmill and in the fashion of increasing manner. Diabetes was induced via injection of 50 (ml/Kg rat weight) STZ. Fifty (ml/kg rat weight) curcumin had being nourished to the animals of the curcumin groups, by using the gavage technique, during a period of eight weeks (five days a week). The rats were anesthetized via intraperitoneal injection of ketamine, 24 hrs after the intervention. Then, The blood was taken from the heart of the rats to examine changes  glucose and insulin resistance. Resultus: Concentration level of glucose and  insulin resistance of the three groups of curcumin, training-placebo, and training-curcumin decreseded significantly than correspondent levels of the control group(P≤0.05). Though, no significant difference was observed, between those three groups (P≤0.05). Conclusion :The results of the present study have indicated that Despite the significant effect of training and curcumin Concentration  of glucose and  insulin resistance, but those two interventions  would not strengthen the influences of each other