Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas).

The role of meconium in the respiratory system was studied in newborns, who died from various causes (250 up to 3000 g of weight). We monitored tracheal rings response to dopamine, serotonin and ethanol in different concentrations (dopamine: 0,05 mg/ml, 0,5 mg/ml, 5 mg/ml; serotonin (5-HT): 10-4, 10...

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Main Authors: Hilmi Islami, Sadi Bexheti, Ragip Shabani, Bajram Nuraj, Fehmi Zeqiri, Aziz Šukalo, Ilir Kurtishi, Skender Kutllovci, Hasime Qorraj, Mentor Disha
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2009-11-01
Series:Bosnian Journal of Basic Medical Sciences
Subjects:
Online Access:http://www.bjbms.org/ojs/index.php/bjbms/article/view/2791
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spelling doaj-5b3e64fb11334e74a526eebd9f25da1f2020-11-24T23:47:27ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBosnian Journal of Basic Medical Sciences1512-86011840-48122009-11-019410.17305/bjbms.2009.2791483Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas).Hilmi Islami0Sadi Bexheti1Ragip Shabani2Bajram Nuraj3Fehmi Zeqiri4Aziz Šukalo5Ilir Kurtishi6Skender Kutllovci7Hasime Qorraj8Mentor Disha9Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinics CenterDepartment of Anatomy, Faculty of Medicine, University of Prishtina, Clinics CentreDepartment of Pathology, Faculty of Medicine, University of Prishtina, Clinics CentreDepartment of Anatomy, Faculty of Medicine, University of Prishtina, Clinics CentreDepartment of Gynecology, Faculty of Medicine, University of Prishtina, Clinics CentreDrugs Factory “Bosnalijek dd”Department of Physiology, Faculty of Medicine, University of Prishtina, Clinical CentreDrugs Factory “Bosnalijek dd”Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinics CenterDepartment of Pharmacology, Faculty of Medicine, University of Prishtina, Clinics CenterThe role of meconium in the respiratory system was studied in newborns, who died from various causes (250 up to 3000 g of weight). We monitored tracheal rings response to dopamine, serotonin and ethanol in different concentrations (dopamine: 0,05 mg/ml, 0,5 mg/ml, 5 mg/ml; serotonin (5-HT): 10-4, 10-3, 10-2, 10-1 mol/dm3; ethanol: 0,02 ml, 0,5 ml, 1,0 ml; 96%). Tracheal smooth musculature tonus (TSM) was examined in 48 tracheal preparations taken after the newborn exitus due to different reasons. Based on functional researche of isolated preparations of tracheas, it may be concluded that: aspiration of me-conium has not changed the response of TSM to dopamine, serotonin and ethanol (p>0,1) in comparison with the control group, which have died due to different lung inflammatory processes (e.g. pneumonia, bronchopneumonia, atelectasis, cerebral hemorrhage). The results suggest that meconium does not potentiate the constricting action of dopamine, serotonin and ethanol in tracheobronchial system. Meconium causes mild relaxation of the TSM through a mechanism that is not intermediated by the products of cyclooxygenases (prostaglandins, prostacyclins) from the tracheal epithelium or proteins. Also, as it seems, the direct activity of many tested acids in the smooth musculature has no significant impact on increase of the airways tonus in MAS syndrome.http://www.bjbms.org/ojs/index.php/bjbms/article/view/2791Tracheameconiumdopamineserotonineethanol
collection DOAJ
language English
format Article
sources DOAJ
author Hilmi Islami
Sadi Bexheti
Ragip Shabani
Bajram Nuraj
Fehmi Zeqiri
Aziz Šukalo
Ilir Kurtishi
Skender Kutllovci
Hasime Qorraj
Mentor Disha
spellingShingle Hilmi Islami
Sadi Bexheti
Ragip Shabani
Bajram Nuraj
Fehmi Zeqiri
Aziz Šukalo
Ilir Kurtishi
Skender Kutllovci
Hasime Qorraj
Mentor Disha
Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas).
Bosnian Journal of Basic Medical Sciences
Trachea
meconium
dopamine
serotonine
ethanol
author_facet Hilmi Islami
Sadi Bexheti
Ragip Shabani
Bajram Nuraj
Fehmi Zeqiri
Aziz Šukalo
Ilir Kurtishi
Skender Kutllovci
Hasime Qorraj
Mentor Disha
author_sort Hilmi Islami
title Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas).
title_short Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas).
title_full Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas).
title_fullStr Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas).
title_full_unstemmed Role of Meconium in the Reaction of Airways Smooth Musculature in the Newborn with Meconium Aspiration Syndrome (Mas).
title_sort role of meconium in the reaction of airways smooth musculature in the newborn with meconium aspiration syndrome (mas).
publisher Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
series Bosnian Journal of Basic Medical Sciences
issn 1512-8601
1840-4812
publishDate 2009-11-01
description The role of meconium in the respiratory system was studied in newborns, who died from various causes (250 up to 3000 g of weight). We monitored tracheal rings response to dopamine, serotonin and ethanol in different concentrations (dopamine: 0,05 mg/ml, 0,5 mg/ml, 5 mg/ml; serotonin (5-HT): 10-4, 10-3, 10-2, 10-1 mol/dm3; ethanol: 0,02 ml, 0,5 ml, 1,0 ml; 96%). Tracheal smooth musculature tonus (TSM) was examined in 48 tracheal preparations taken after the newborn exitus due to different reasons. Based on functional researche of isolated preparations of tracheas, it may be concluded that: aspiration of me-conium has not changed the response of TSM to dopamine, serotonin and ethanol (p>0,1) in comparison with the control group, which have died due to different lung inflammatory processes (e.g. pneumonia, bronchopneumonia, atelectasis, cerebral hemorrhage). The results suggest that meconium does not potentiate the constricting action of dopamine, serotonin and ethanol in tracheobronchial system. Meconium causes mild relaxation of the TSM through a mechanism that is not intermediated by the products of cyclooxygenases (prostaglandins, prostacyclins) from the tracheal epithelium or proteins. Also, as it seems, the direct activity of many tested acids in the smooth musculature has no significant impact on increase of the airways tonus in MAS syndrome.
topic Trachea
meconium
dopamine
serotonine
ethanol
url http://www.bjbms.org/ojs/index.php/bjbms/article/view/2791
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