NKG2D is a key receptor for recognition of bladder cancer cells by IL-2-activated NK cells and BCG promotes NK cell activation

NKG2D is a key receptor for recognition of bladder cancer cells by IL-2-activated NK cells and BCG promotes NK cell activation

Intravesical instillation of Bacillus Calmette-Guérin (BCG) is used to treat superficial bladder cancer, either papillary tumors (after trans-urethral resection) or high-grade flat carcinomas (carcinoma in situ), reducing recurrence in about 70% of patients. Initially, BCG was proposed to work throu...

Full description

Bibliographic Details
Main Authors: Eva María García-Cuesta, Sheila eLópez-Cobo, Mario eÁlvarez-Maestro, Gloria eEsteso, Gema eRomera, Mercedes eRey, Robin L Cassady-Cain, Alejandro eValés-Gómez, Hugh Thomson Reyburn, Luis eMartínez-Piñeiro, Mar eVales-Gomez
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium bovis
Bladder cancer
Natural Killer cells
NKG2D
Natural cytotoxicity receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00284/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00284/full

Similar Items