Development of Zika Virus Vaccines

Development of Zika Virus Vaccines

Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged as a global threat following the most recent outbreak in Brazil in 2015. ZIKV infection of pregnant women is associated with fetal abnormalities such as microcephaly, and infection of adults can lead to Guillain–Barré syndrome, an autoimm...

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Main Authors: Huda Makhluf, Sujan Shresta
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Vaccines
Subjects:
Zika virus
dengue virus
vaccines
Online Access:http://www.mdpi.com/2076-393X/6/1/7
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spelling doaj-5b2bf964a99049299182f98776a25c9f2020-11-24T23:16:19ZengMDPI AGVaccines2076-393X2018-01-0161710.3390/vaccines6010007vaccines6010007Development of Zika Virus VaccinesHuda Makhluf0Sujan Shresta1Department of Mathematics and Natural Sciences, National University, La Jolla, CA 92037, USACenter for Infectious Disease, La Jolla Institute, La Jolla, CA 92037, USAZika virus (ZIKV) is a mosquito-borne flavivirus that emerged as a global threat following the most recent outbreak in Brazil in 2015. ZIKV infection of pregnant women is associated with fetal abnormalities such as microcephaly, and infection of adults can lead to Guillain–Barré syndrome, an autoimmune disease characterized by neurological deficits. Although there are currently licensed vaccines for other flaviviruses, there remains an urgent need for preventative vaccines against ZIKV infection. Herein we describe the current efforts to accelerate the development of ZIKV vaccines using various platforms, including live attenuated virus, inactivated virus, DNA and RNA, viral vectors, and in silico-predicted immunogenic viral epitopes. Many of these approaches have leveraged lessons learned from past experience with Dengue and other flavivirus vaccines.http://www.mdpi.com/2076-393X/6/1/7Zika virusdengue virusvaccines
collection DOAJ
language English
format Article
sources DOAJ
author Huda Makhluf
Sujan Shresta
spellingShingle Huda Makhluf
Sujan Shresta
Development of Zika Virus Vaccines
Vaccines
Zika virus
dengue virus
vaccines
author_facet Huda Makhluf
Sujan Shresta
author_sort Huda Makhluf
title Development of Zika Virus Vaccines
title_short Development of Zika Virus Vaccines
title_full Development of Zika Virus Vaccines
title_fullStr Development of Zika Virus Vaccines
title_full_unstemmed Development of Zika Virus Vaccines
title_sort development of zika virus vaccines
publisher MDPI AG
series Vaccines
issn 2076-393X
publishDate 2018-01-01
description Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged as a global threat following the most recent outbreak in Brazil in 2015. ZIKV infection of pregnant women is associated with fetal abnormalities such as microcephaly, and infection of adults can lead to Guillain–Barré syndrome, an autoimmune disease characterized by neurological deficits. Although there are currently licensed vaccines for other flaviviruses, there remains an urgent need for preventative vaccines against ZIKV infection. Herein we describe the current efforts to accelerate the development of ZIKV vaccines using various platforms, including live attenuated virus, inactivated virus, DNA and RNA, viral vectors, and in silico-predicted immunogenic viral epitopes. Many of these approaches have leveraged lessons learned from past experience with Dengue and other flavivirus vaccines.
topic Zika virus
dengue virus
vaccines
url http://www.mdpi.com/2076-393X/6/1/7
work_keys_str_mv AT hudamakhluf developmentofzikavirusvaccines
AT sujanshresta developmentofzikavirusvaccines
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