GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.

GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.

Our previous studies showed a down-regulation of GRIM-19 in primary human cervical cancers, and restoration of GRIM-19 induced tumor regression. The induction of tumor suppressor protein p53 ubiquitination and degradation by E6 oncoportein of high risk-HPV through forming a stable complex with E6AP...

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Main Authors: Ying Zhou, Ying Wei, Jing Zhu, Qingyuan Wang, Liang Bao, Yang Ma, Yu Chen, Dingqing Feng, Aijin Zhang, Jie Sun, Shreeram C Nallar, Keng Shen, Dhananjaya V Kalvakolanu, Weihua Xiao, Bin Ling
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3134474?pdf=render

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