The Involvement of Renin-Angiotensin System in Lipopolysaccharide-Induced Behavioral Changes, Neuroinflammation, and Disturbed Insulin Signaling

The Involvement of Renin-Angiotensin System in Lipopolysaccharide-Induced Behavioral Changes, Neuroinflammation, and Disturbed Insulin Signaling

Brain insulin signaling is accounted for the development of a variety of neuropsychiatric disorders, such as anxiety and depression, whereas both inflammation and the activated renin-angiotensin system (RAS) are two major contributors to insulin resistance. Intriguingly, inflammation and RAS can act...

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Bibliographic Details
Main Authors: Xiaoxue Gong, Hui Hu, Yi Qiao, Pengfei Xu, Mengqi Yang, Ruili Dang, Wenxiu Han, Yujin Guo, Dan Chen, Pei Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
lipopolysaccharide
depression
renin-angiotensin system
inflammation
insulin pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00318/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00318/full

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