Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir.

Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir.

Nelfinavir is a potent HIV-protease inhibitor with pleiotropic effects in cancer cells. Experimental studies connect its anti-cancer effects to the suppression of the Akt signaling pathway, but the actual molecular targets remain unknown. Using a structural proteome-wide off-target pipeline, which i...

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Bibliographic Details
Main Authors: Li Xie, Thomas Evangelidis, Lei Xie, Philip E Bourne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3084228?pdf=render

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