Effects of omega-3 administration on homocysteine serum concentration in renal transplant recipient.
Background: It has been shown that serum total homocysteine (HC) is a risk factor for vascular disease which characterizes endothelial damage in the general and in the End-Stage Renal Disease (ESRD) population as well. Whether n-3 polyunsaturated fatty acids decrease homocysteine (Hcy) level has be...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Research Center for Rational Use of Drugs (RCRUD)
2015-10-01
|
| Series: | Journal of Pharmaceutical Care |
| Subjects: | |
| Online Access: | https://jpc.tums.ac.ir/index.php/jpc/article/view/6 |
| Summary: | Background: It has been shown that serum total homocysteine (HC) is a risk factor for vascular disease which characterizes endothelial damage in the general and in the End-Stage Renal Disease (ESRD) population as well. Whether n-3 polyunsaturated fatty acids decrease homocysteine (Hcy) level has been a subject of controversy.
Methods: Renal transplant patients were randomized in 2 groups and received 6 months of dietary supplementation with 6 g/day of Fish oil or placebo. Homocysteine level and total cholesterol level were measured.
Results: In 40 renal transplant recipients, increase in homocysteine level was greater after Fish oil administration but not significantly, total cholesterol was decreased significantly.
Conclusion: Based on these data omega3 fatty acids supplementation doesn’t decrease serum homocysteine in renal transplant recipients but decreases total cholesterol level.
|
|---|---|
| ISSN: | 2322-4630 2322-4509 |