Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents

Combination of arylidene hydrazinyl moiety with pyrido[2,3-d]pyrimidin-4-one skeleton in compounds 7‒26 results in the output of unprecedented anti-microbial agents. Arylidene hydrazinyl based on Pyrido[2,3-d]pyrimidin-4-one analoges 7‒26 prepared by the treatment of [2,3-d]pyrimidin-4-ones 6a,b wit...

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Main Authors:	Reda M. Abdelhameed, Osama M. Darwesh, Mahmoud El-Shahat
Format:	Article
Language:	English
Published:	Elsevier 2020-09-01
Series:	Heliyon
Subjects:	Organic chemistry Pharmaceutical chemistry Pyrido[2,3-d]pyrimidin-4-one Hydrazinylpyrido[2,3-d]pyrimidin-4-one Anti-bacterial activity Anti-fungal activity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844020317990

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spelling	doaj-5b1a92342bdd49da81e81381f5f284d82020-11-25T03:53:41ZengElsevierHeliyon2405-84402020-09-0169e04956Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agentsReda M. Abdelhameed0Osama M. Darwesh1Mahmoud El-Shahat2Applied Organic Chemistry Department, Chemical Industries Research Division, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza, 12622, EgyptDepartment of Agricultural Microbiology, Agricultural Research Division, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza, 12622, EgyptPhotochemistry Department, Chemical Industries Research Division, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza 12622, Egypt; Corresponding author.Combination of arylidene hydrazinyl moiety with pyrido[2,3-d]pyrimidin-4-one skeleton in compounds 7‒26 results in the output of unprecedented anti-microbial agents. Arylidene hydrazinyl based on Pyrido[2,3-d]pyrimidin-4-one analoges 7‒26 prepared by the treatment of [2,3-d]pyrimidin-4-ones 6a,b with various aromatic aldehydes. The antimicrobial action for recently synthesized compounds was considered towards gram positive bacterial species (Staphylococcus aurous ATCC- 47077; Bacillus cereus ATCC-12228), gram negative bacterial species (Escherichia coli ATCC-25922; Salmonella typhi ATCC-15566) and Candida albicans ATCC-10231 as fungal strains. The antimicrobial action expanded by expanding the electron donating group in position 2 and 5 for Pyrido[2,3-d]pyrimidin-4-one core. Derivatives 13, 14, 15, 16 and 12; individually appeared hopeful anti-microbial action towards all strains utilized with inhibition zone higher than that of standard reference drug with lowest MIC.http://www.sciencedirect.com/science/article/pii/S2405844020317990Organic chemistryPharmaceutical chemistryPyrido[2,3-d]pyrimidin-4-oneHydrazinylpyrido[2,3-d]pyrimidin-4-oneAnti-bacterial activityAnti-fungal activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Reda M. Abdelhameed Osama M. Darwesh Mahmoud El-Shahat
spellingShingle	Reda M. Abdelhameed Osama M. Darwesh Mahmoud El-Shahat Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents Heliyon Organic chemistry Pharmaceutical chemistry Pyrido[2,3-d]pyrimidin-4-one Hydrazinylpyrido[2,3-d]pyrimidin-4-one Anti-bacterial activity Anti-fungal activity
author_facet	Reda M. Abdelhameed Osama M. Darwesh Mahmoud El-Shahat
author_sort	Reda M. Abdelhameed
title	Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents
title_short	Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents
title_full	Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents
title_fullStr	Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents
title_full_unstemmed	Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents
title_sort	synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents
publisher	Elsevier
series	Heliyon
issn	2405-8440
publishDate	2020-09-01
description	Combination of arylidene hydrazinyl moiety with pyrido[2,3-d]pyrimidin-4-one skeleton in compounds 7‒26 results in the output of unprecedented anti-microbial agents. Arylidene hydrazinyl based on Pyrido[2,3-d]pyrimidin-4-one analoges 7‒26 prepared by the treatment of [2,3-d]pyrimidin-4-ones 6a,b with various aromatic aldehydes. The antimicrobial action for recently synthesized compounds was considered towards gram positive bacterial species (Staphylococcus aurous ATCC- 47077; Bacillus cereus ATCC-12228), gram negative bacterial species (Escherichia coli ATCC-25922; Salmonella typhi ATCC-15566) and Candida albicans ATCC-10231 as fungal strains. The antimicrobial action expanded by expanding the electron donating group in position 2 and 5 for Pyrido[2,3-d]pyrimidin-4-one core. Derivatives 13, 14, 15, 16 and 12; individually appeared hopeful anti-microbial action towards all strains utilized with inhibition zone higher than that of standard reference drug with lowest MIC.
topic	Organic chemistry Pharmaceutical chemistry Pyrido[2,3-d]pyrimidin-4-one Hydrazinylpyrido[2,3-d]pyrimidin-4-one Anti-bacterial activity Anti-fungal activity
url	http://www.sciencedirect.com/science/article/pii/S2405844020317990
work_keys_str_mv	AT redamabdelhameed synthesisofarylidenehydrazinylpyrido23dpyrimidin4onesaspotentantimicrobialagents AT osamamdarwesh synthesisofarylidenehydrazinylpyrido23dpyrimidin4onesaspotentantimicrobialagents AT mahmoudelshahat synthesisofarylidenehydrazinylpyrido23dpyrimidin4onesaspotentantimicrobialagents
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Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents

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