The Utilization of Freezing Steps in Mesenchymal Stromal Cell (MSC) Manufacturing: Potential Impact on Quality and Cell Functionality Attributes

The Utilization of Freezing Steps in Mesenchymal Stromal Cell (MSC) Manufacturing: Potential Impact on Quality and Cell Functionality Attributes

Some recent reports suggest that cryopreserved and thawed mesenchymal stromal cells (MSCs) may have impaired functional properties as compared to freshly harvested MSCs from continuous cultures. A cryopreservation step in the manufacturing process brings important benefits, since it enables immediat...

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Bibliographic Details
Main Authors: Sofia Oja, Tanja Kaartinen, Marja Ahti, Matti Korhonen, Anita Laitinen, Johanna Nystedt
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
cryopreservation
freezing
MSC
mesenchymal stromal cell
immunosuppression
cell banking
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01627/full

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