Coronary Angiography-Derived Diastolic Pressure Ratio

• Main Authors: Yanjun Gong, Yundi Feng, Tieci Yi, Fan Yang, Yuxi Li, Long Zhang, Bo Zheng, Tao Hong, Zhaoping Liu, Yunlong Huo, Jianping Li, Yong Huo
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-10-01
• Series: Frontiers in Bioengineering and Biotechnology
• Subjects: IFR; DPR; FFR; CFD; hemodynamics
• Online Access: https://www.frontiersin.org/articles/10.3389/fbioe.2020.596401/full

AimsBased on the aortic pressure waveform, a specially designed computational fluid dynamic (CFD) method was proposed to determine coronary angiography-derived diastolic pressure ratio (caDPR) without using invasive pressure wire. The aim of the study is to retrospectively assess diagnostic performance of the caDPR in the catheterization laboratory, based on a previous multicenter trial for online assessment of coronary angiography-derived FFR (caFFR).Methods and ResultsPatients with diagnosis of stable or unstable angina pectoris were enrolled in six centers. Wire-derived FFR was measured in coronary arteries with 30–90% diameter stenosis. Offline caDPR was assessed in blinded fashion against wire-derived FFR at an independent core laboratory. A total of 330 patients who met the inclusion/exclusion criteria were enrolled from June 26 to December 18, 2018. Offline computed caDPR and wire-derived FFR were compared in 328 interrogated vessels. The caDPR with a cutoff value of 0.89 shows diagnostic accuracy of 87.7%, sensitivity of 89.5%, specificity of 86.8%, and AUC of 0.940 against the wire-derived FFR with a cutoff value of 0.80.ConclusionsUsing wired-based FFR as the standard reference, there is good diagnostic performance of the novel-CFD-design caDPR. Hence, caDPR could enhance the hemodynamic assessment of coronary lesions.