Overexpression of Protein Tyrosine Phosphatase 1B in HepG2 Cells Ameliorates Insulin-mediated Suppression of Apolipoprotein B mRNA Translation Via Its Untranslated Regions

Overexpression of Protein Tyrosine Phosphatase 1B in HepG2 Cells Ameliorates Insulin-mediated Suppression of Apolipoprotein B mRNA Translation Via Its Untranslated Regions

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Background: The hepatic secretion of apolipoprotein B (apoB), containing lipoproteins, is known to be regulated by insulin, and the overproduction of these atherogenic lipoproteins occurs in insulin-resistant states. Protein tyrosine phosphatase 1B (PTP-1B) is a key regulator of hepatic insulin sign...

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Bibliographic Details
Main Authors: Gus Sidiropoulos, Rita Kohen Avramoglu, Wei Qiu, Parvin Pasalar, Khosrow Adeli
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2007-07-01
Series:Journal of Tehran University Heart Center
Subjects:
Protein tyrosine phosphatase 1B
Untranslated region
In vitro translation assay
Online Access:http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4022.pdf&manuscript_id=4022

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http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4022.pdf&manuscript_id=4022

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