Diacetylenic lipids in the design of stable lipopolymers able to complex and protect plasmid DNA.
Different viral and non-viral vectors have been designed to allow the delivery of nucleic acids in gene therapy. In general, non-viral vectors have been associated with increased safety for in vivo use; however, issues regarding their efficacy, toxicity and stability continue to drive further resear...
Main Authors: | C Facundo Temprana, M Jimena Prieto, Daniela E Igartúa, A Lis Femia, M Silvia Amor, Silvia Del Valle Alonso |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5636127?pdf=render |
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