Effects of TMK-688 a potent 5-lipoxygenase inhibitor, on dual-phase asthmatic response in conscious guinea pigs sensitized with ovalbumin

Effects of TMK-688 a potent 5-lipoxygenase inhibitor, on dual-phase asthmatic response in conscious guinea pigs sensitized with ovalbumin

We evaluated the anti-asthmatic effects and mechanism of action of TMK-688, a potent 5-lipoxygenase inhibitor, on the dual-phase asthmatic response and on airway inflammation in conscious guinea pigs sensitized with ovalbumin (OA). TMK-688 inhibited both the immediate and the late asthmatic response...

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Bibliographic Details
Main Authors: Yuji Tohda, Masato Muraki, Hirokazu Kubo, Shigenori Nakajima
Format: Article
Language:English
Published: Elsevier 1997-01-01
Series:Allergology International
Subjects:
airway hyperreactivity
bronchoalveolar lavage cell
dual-phase asthmatic response model
guinea pigs
late asthmatic response
reactive oxygen
TMK-688
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015315872

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http://www.sciencedirect.com/science/article/pii/S1323893015315872

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