Positive Predictive Values in Diagnosis of Incidental Prostate Cancer

• Main Authors: Caner Ediz, Ayşe Nur İhvan, Hüseyin Hayit, Nermin Koç, Cumhur Selçuk Topal
• Format: Article
• Language: English
• Published: Dicle University Medical School 2016-03-01
• Series: Dicle Medical Journal
• Subjects: Incidental prostate cancer; clinic parameters
• Online Access: http://www.diclemedj.org/upload/sayi/59/Dicle%20Med%20J-02895.pdf
• ISSN: 1300-2945; 1308-9889

Objective: Although the incidence of incidental prostate cancer (IPCa) decreases in recent years; for patients who performed by transurethral resection of the prostate (TURP) due to bladder outlet obstruction with or without prostatism symptoms (BPH), it is still can be seen. This article purposes to answer two questions a) for urologist, which clinical parameters including obesity and smoking have positive predictive value. b) for pathologists; which materials are wholly sampled for reducing the cancer ? Methods: We evaluated 1315 cases who were per­formed by TURP due to bladder outlet obstruction with or without prostatism symptoms the years 2006-2015. The ages of the patients, smoking, body mass index (BMI), digital rectal examination (DRE) findings, preoperative prostate specific antigen (PSA) levels, uroflow values, to­tal prostate volume determined by suprapubic ultrasound and Gleason score were recorded. We analyzed the re­lationship between these parameters and IPCa. These situation compared with benign prostate tissue materials. Results: Totally 31 cases (2.35%) were found in the IPCa. While the cases of 24 were pT1a, 7 cases were pT1b. Age, body mass index, PSA, peak current speed and mean flow rate parameters respectively 8.887, 5.668, 9.660, 4.814 and 3.716 times as an incidental effect in detecting prostate cancer has been concluded. Conclusion: Older patient age, over the 25 kg/m2 of BMI, over the 4 ng/dl of PSA levels, the peak flow rate less than 10 ml/sec and the mean flow rate less than 5 ml/sec might be independent risk factors for detecting IPCa. More ex­ternal validation is needed for confirming our results.