Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells

Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells

Summary: Pyruvate is a key metabolite in glycolysis and the tricarboxylic acid (TCA) cycle. Exogenous pyruvate modulates metabolism, provides cellular protection, and is essential for the maintenance of human preimplantation embryos and human embryonic stem cells (hESCs). However, little is known ab...

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Bibliographic Details
Main Authors: Chengcheng Song, Faxiang Xu, Zhili Ren, Yumeng Zhang, Ya Meng, Yiqi Yang, Shreyas Lingadahalli, Edwin Cheung, Gang Li, Weiwei Liu, Jianbo Wan, Yang Zhao, Guokai Chen
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119302292

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