Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives

Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives

Objectives: So far, few studies have investigated cortical thickness (CT) and surface area (SA) measures in bipolar disorder type I (BDI) in comparison to a high genetic risk group such as first-degree relatives (FR). This study aimed to examine CT and SA differences between BDI, FR and healthy cont...

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Main Authors: Nefize Yalin, Aybala Saricicek, Ceren Hidiroglu, Andre Zugman, Nese Direk, Emel Ada, Berrin Cavusoglu, Ayşe Er, Gizem Isik, Deniz Ceylan, Zeliha Tunca, Matthew J. Kempton, Aysegul Ozerdem
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:NeuroImage: Clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158219300452
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spelling doaj-5af9d76b385444bc9f4370b40a5d8e6a2020-11-25T01:20:32ZengElsevierNeuroImage: Clinical2213-15822019-01-0122Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relativesNefize Yalin0Aybala Saricicek1Ceren Hidiroglu2Andre Zugman3Nese Direk4Emel Ada5Berrin Cavusoglu6Ayşe Er7Gizem Isik8Deniz Ceylan9Zeliha Tunca10Matthew J. Kempton11Aysegul Ozerdem12Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey; Corresponding author at: Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, PO 72, London SE58AF, UK.Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey; Department of Psychiatry, Faculty of Medicine, Katip Celebi University, Izmir, TurkeyDepartment of Psychology, Faculty of Arts, Dokuz Eylul University, Izmir, TurkeyInterdisciplinary Laboratory of Clinical Neuroscience (LINC), Department of Psychiatry, Universidade Federal de Sao Paulo, Sao Paulo, BrazilDepartment of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, TurkeyDepartment of Radiology, Faculty of Medicine, Dokuz Eylul University, Izmir, TurkeyDepartment of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, TurkeyDepartment of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, TurkeyDepartment of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, TurkeyDepartment of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, TurkeyDepartment of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, TurkeyDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UKDepartment of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey; Department of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, TurkeyObjectives: So far, few studies have investigated cortical thickness (CT) and surface area (SA) measures in bipolar disorder type I (BDI) in comparison to a high genetic risk group such as first-degree relatives (FR). This study aimed to examine CT and SA differences between BDI, FR and healthy controls (HC). Methods: 3D T1 magnetic resonance images were acquired from 27 euthymic BDI patients, 24 unaffected FR and 29 HC. CT and SA measures were obtained with FreeSurfer version 5.3.0. Generalized estimating equations were used to compare CT and SA between groups. Group comparisons were repeated with restricting the FR group to 17 siblings (FR-SB) only. Results: Mean age in years was 36.3 ± 9.5 for BDI, 32.1 ± 10.9 for FR, 34.7 ± 9.8 for FR-SB and 33.1 ± 9.0 for HC group respectively. BDI patients revealed larger SA of left pars triangularis (LPT) compared to HC (p = .001). In addition, increased SA in superior temporal cortex (STC) in FR-SB group compared to HC was identified (p = .0001). Conclusions: Our result of increased SA in LPT of BDI could be a disease marker and increased SA in STC of FR-SB could be a marker related with resilience to illness. Keywords: Bipolar disorder type I, First-degree relative, Cortical thickness, Endophenotype, Surface areahttp://www.sciencedirect.com/science/article/pii/S2213158219300452
collection DOAJ
language English
format Article
sources DOAJ
author Nefize Yalin
Aybala Saricicek
Ceren Hidiroglu
Andre Zugman
Nese Direk
Emel Ada
Berrin Cavusoglu
Ayşe Er
Gizem Isik
Deniz Ceylan
Zeliha Tunca
Matthew J. Kempton
Aysegul Ozerdem
spellingShingle Nefize Yalin
Aybala Saricicek
Ceren Hidiroglu
Andre Zugman
Nese Direk
Emel Ada
Berrin Cavusoglu
Ayşe Er
Gizem Isik
Deniz Ceylan
Zeliha Tunca
Matthew J. Kempton
Aysegul Ozerdem
Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
NeuroImage: Clinical
author_facet Nefize Yalin
Aybala Saricicek
Ceren Hidiroglu
Andre Zugman
Nese Direk
Emel Ada
Berrin Cavusoglu
Ayşe Er
Gizem Isik
Deniz Ceylan
Zeliha Tunca
Matthew J. Kempton
Aysegul Ozerdem
author_sort Nefize Yalin
title Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
title_short Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
title_full Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
title_fullStr Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
title_full_unstemmed Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives
title_sort cortical thickness and surface area as an endophenotype in bipolar disorder type i patients and their first-degree relatives
publisher Elsevier
series NeuroImage: Clinical
issn 2213-1582
publishDate 2019-01-01
description Objectives: So far, few studies have investigated cortical thickness (CT) and surface area (SA) measures in bipolar disorder type I (BDI) in comparison to a high genetic risk group such as first-degree relatives (FR). This study aimed to examine CT and SA differences between BDI, FR and healthy controls (HC). Methods: 3D T1 magnetic resonance images were acquired from 27 euthymic BDI patients, 24 unaffected FR and 29 HC. CT and SA measures were obtained with FreeSurfer version 5.3.0. Generalized estimating equations were used to compare CT and SA between groups. Group comparisons were repeated with restricting the FR group to 17 siblings (FR-SB) only. Results: Mean age in years was 36.3 ± 9.5 for BDI, 32.1 ± 10.9 for FR, 34.7 ± 9.8 for FR-SB and 33.1 ± 9.0 for HC group respectively. BDI patients revealed larger SA of left pars triangularis (LPT) compared to HC (p = .001). In addition, increased SA in superior temporal cortex (STC) in FR-SB group compared to HC was identified (p = .0001). Conclusions: Our result of increased SA in LPT of BDI could be a disease marker and increased SA in STC of FR-SB could be a marker related with resilience to illness. Keywords: Bipolar disorder type I, First-degree relative, Cortical thickness, Endophenotype, Surface area
url http://www.sciencedirect.com/science/article/pii/S2213158219300452
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