Screening of drugs inhibiting in vitro oligomerization of Cu/Zn-superoxide dismutase with a mutation causing amyotrophic lateral sclerosis

Screening of drugs inhibiting in vitro oligomerization of Cu/Zn-superoxide dismutase with a mutation causing amyotrophic lateral sclerosis

Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) gene have been shown to cause a familial form of amyotrophic lateral sclerosis (SOD1-ALS). A major pathological hallmark of this disease is abnormal accumulation of mutant SOD1 oligomers in the affected spinal motor neurons. While no effectiv...

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Bibliographic Details
Main Authors: Itsuki Anzai, Keisuke Toichi, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama, Yoshiaki Furukawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
Amyotrophic Lateral Sclerosis
drug screening
protein aggregation
protein misfolding
Cu/Zn-superoxide dismutase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00040/full

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