Effect of regular anti-osteoporosis treatment on bone mineral density and bone metabolism in patients with primary osteoporosis and its relationship with bone fractures
Objective: To analyze the effect of regular anti-osteoporosis treatment on bone mineral density and bone metabolism in patients with primary osteoporosis and its relationship with bone fractures. Methods: A total of 120 patients with primary osteoporosis were included in this study and randomly d...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2016-12-01
|
| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201624/24.pdf |
| Summary: | Objective: To analyze the effect of regular anti-osteoporosis treatment on bone mineral
density and bone metabolism in patients with primary osteoporosis and its relationship with
bone fractures. Methods: A total of 120 patients with primary osteoporosis were included in
this study and randomly divided into observation group and control group (n=60). Control
group received consistent treatment, observation group received individualized regular antiosteoporosis
treatment, and then the differences in bone mineral density, bone metabolism,
trace elements, oxidative stress, fracture incidence, and so on were compared between two
groups of patients 1 year after treatment. Results: Absolute BMD value of observation group
after treatment was higher than that of control group; serum bone formation indexes ALP, BGP,
PⅠNP and PⅠCP content were higher than those of control group; serum bone resorption
indexes β-CTX, sRANKL, TRACP, BAP and DPD content were lower than those of control
group; serum trace elements iron and zinc content were higher than those of control group
while calcium content was lower than that of control group; serum AOPP and MAOA content
of observation group were significantly lower than those of control group while SOD and
T-AOC content were significantly higher than those of control group;fracture incidence was
significantly lower than that of control group during treatment. Conclusions: The regular antiosteoporosis
treatment can increase bone mineral density, optimize the overall condition and
reduce the incidence of long-term fracture in patients with primary osteoporosis. |
|---|---|
| ISSN: | 1007-1237 1007-1237 |