Loss of intestinal sympathetic innervation elicits an innate immune driven colitis

Loss of intestinal sympathetic innervation elicits an innate immune driven colitis

Abstract Background Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in intestinal mucosa is reduced. Our aim was to investigate the role of sympathetic innervation to the intestine on regulatio...

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Bibliographic Details
Main Authors: Rose A. Willemze, Olaf Welting, Patricia van Hamersveld, Caroline Verseijden, Laurens E. Nijhuis, Francisca W. Hilbers, Sybren L. Meijer, Balthasar A. Heesters, Joost H. A. Folgering, Harold Darwinkel, Philippe Blancou, Margriet J. Vervoordeldonk, Jurgen Seppen, Sigrid E. M. Heinsbroek, Wouter J. de Jonge
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Molecular Medicine
Subjects:
Inflammatory bowel disease
Colitis
Autonomic nervous system
Sympathetic innervation
Norepinephrine
Online Access:http://link.springer.com/article/10.1186/s10020-018-0068-8

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http://link.springer.com/article/10.1186/s10020-018-0068-8

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