Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice

Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice

Background Mesenchymal stem/stromal cells (MSCs) are a promising tool for cell-based therapies in the treatment of tissue injury. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis plays a significant role in directing MSC homing to sites of injury. However in vivo MSC d...

Full description

Bibliographic Details
Main Authors:	Wang Jin, Xiaowen Liang, Anastasia Brooks, Kathryn Futrega, Xin Liu, Michael R. Doran, Matthew J. Simpson, Michael S. Roberts, Haolu Wang
Format:	Article
Language:	English
Published:	PeerJ Inc. 2018-12-01
Series:	PeerJ
Subjects:	Mesenchymal stem cells Stem cell transplantation Chemotaxis Mathematical modelling In vivo homing
Online Access:	https://peerj.com/articles/6072.pdf

Similar Items

Engraftment Outcomes after HPC Co-Culture with Mesenchymal Stromal Cells and Osteoblasts
by: Matthew M. Cook, et al.
Published: (2013-09-01)

Induction of Regulatory B-Cells by Mesenchymal Stem Cells is Affected by SDF-1α-CXCR7
by: Yan Qin, et al.
Published: (2015-08-01)

Mesenchymal Stromal/Stem cells: Historical perspective and ongoing challenges
by: Maria Isabel Doria Rossi, et al.
Published: (2020-06-01)

CXCL12/SDF-1 and CXCR4
by: Takashi eNagasawa
Published: (2015-06-01)

SDF-1α/CXCR4 Axis Mediates The Migration of Mesenchymal Stem Cells to The Hypoxic-Ischemic Brain Lesion in A Rat Model
by: Qin Yu, et al.
Published: (2015-01-01)

A magic kick for regeneration: role of mesenchymal stromal cell secretome in spermatogonial stem cell niche recovery
by: Georgy Sagaradze, et al.
Published: (2019-11-01)

Editorial: Current Progress in Mesenchymal Stem/Stromal Cell Research
by: Lindolfo da Silva Meirelles, et al.
Published: (2021-02-01)

Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis
by: Yongting Zhang, et al.
Published: (2018-03-01)

The Paracrine Role of Endothelial Cells in Bone Formation via CXCR4/SDF-1 Pathway
by: Tal Tamari, et al.
Published: (2020-05-01)

Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction
by: Dihan Lu, et al.
Published: (2019-04-01)

Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration
by: Georgy D. Sagaradze, et al.
Published: (2020-09-01)

Concise Review: Mesenchymal Stem Cell‐Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise
by: Timothy E. G. Krueger, et al.
Published: (2018-09-01)

Intermittent parathyroid hormone (1–34) supplementation of bone marrow stromal cell cultures may inhibit hypertrophy, but at the expense of chondrogenesis
by: Ena Music, et al.
Published: (2020-07-01)

Mesenchymal Stromal Cell-Derived Extracellular Vesicles – Silver Linings for Cartilage Regeneration?
by: Andrea De Luna, et al.
Published: (2020-12-01)

Mesenchymal stem/stromal cells: Developmental origin, tumorigenesis and translational cancer therapeutics
by: Chenghai Li, et al.
Published: (2021-01-01)

Production of Mesenchymal Stem Cells through Stem Cell Reprogramming
by: Ahmed Abdal Dayem, et al.
Published: (2019-04-01)

The production method affects the efficacy of platelet derivatives to expand mesenchymal stromal cells in vitro
by: Martina Bernardi, et al.
Published: (2017-05-01)

Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging
by: Simona Neri, et al.
Published: (2020-02-01)

Comparison of Tumor- and Bone Marrow-Derived Mesenchymal Stromal/Stem Cells from Patients with High-Grade Osteosarcoma
by: Louis-Romée Le Nail, et al.
Published: (2018-03-01)

Mesenchymal stem cells homing to improve bone healing
by: Weiping Lin, et al.
Published: (2017-04-01)

Reciprocal upregulation of Notch signaling molecules in hematopoietic progenitor and mesenchymal stromal cells
by: Kikuchi Y, et al.
Published: (2011-01-01)

Towards a Treatment of Stress Urinary Incontinence: Application of Mesenchymal Stromal Cells for Regeneration of the Sphincter Muscle
by: Wilhelm K. Aicher, et al.
Published: (2014-02-01)

Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models
by: Popielarczyk, Tracee
Published: (2017)

Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review
by: Trinidad Montero-Vilchez, et al.
Published: (2021-07-01)

Immunomodulatory Properties of Mesenchymal Stromal Cells Can Vary in Genetically Modified Rats
by: Natalie Vallant, et al.
Published: (2021-01-01)

Isolation and characterization of equine endometrial mesenchymal stromal cells
by: B. Elisabeth Rink, et al.
Published: (2017-07-01)

Unveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration
by: Peter P. Nimiritsky, et al.
Published: (2019-02-01)

Neural differentiation of canine mesenchymal stem cells/multipotent mesenchymal stromal cells
by: Sonja Prpar Mihevc, et al.
Published: (2020-08-01)

Mesenchymal Stromal Cells for Transplant Tolerance
by: Manuel Alfredo Podestà, et al.
Published: (2019-06-01)

Mesenchymal stem/stromal cell function in modulating cell death
by: Abderrahim Naji, et al.
Published: (2019-02-01)

Clinical-Grade Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Ameliorate the Progression of Osteoarthritis in a Rat Model
by: Dan Xing, et al.
Published: (2021-01-01)

A focus on allogeneic mesenchymal stromal cells as a versatile therapeutic tool for treating multiple sclerosis
by: Ameneh Shokati, et al.
Published: (2021-07-01)

Effect of Helicobacter pylori infection on stromal-derived factor-1/CXCR4 axis in bone marrow-derived mesenchymal stem cells
by: Shohreh Fakhari, et al.
Published: (2014-01-01)

Effects of mesenchymal stromal cell-derived extracellular vesicles on tumor growth
by: Stefania eBruno, et al.
Published: (2014-08-01)

Cellular Heterogeneity of Mesenchymal Stem/Stromal Cells in the Bone Marrow
by: Yo Mabuchi, et al.
Published: (2021-07-01)

Extracellular vesicles from bone marrow-derived multipotent mesenchymal stromal cells regulate inflammation and enhance tendon healing
by: Zhengzhou Shi, et al.
Published: (2019-06-01)

Rat Mesenchymal Stromal Cell Sheets Suppress Renal Fibrosis via Microvascular Protection
by: Aya Imafuku, et al.
Published: (2019-12-01)

Umbilical Cord-Derived CD362<sup>+</sup> Mesenchymal Stromal Cells Attenuate Polymicrobial Sepsis Induced by Caecal Ligation and Puncture
by: Hector Gonzalez, et al.
Published: (2020-11-01)

CLINICAL EFFECTS OF MESENCHYMAL STROMAL CELLS IN LYMPHOMA PATIENTS WITH AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION
by: E. V. Batorov, et al.
Published: (2012-05-01)

Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm
by: Kan Yin, et al.
Published: (2019-04-01)