The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas

• Main Authors: Ines Garces de los Fayos Alonso, Huan-Chang Liang, Suzanne D. Turner, Sabine Lagger, Olaf Merkel, Lukas Kenner
• Format: Article
• Language: English
• Published: MDPI AG 2018-03-01
• Series: Cancers
• Subjects: Activator Protein-1 (AP-1); Transcription Factors (TFs); Anaplastic Large Cell Lymphoma (ALCL); CD-30; Classical Hodgkin Lymphoma (CHL); Peripheral T-cell Lymphoma (PTCL)
• Online Access: http://www.mdpi.com/2072-6694/10/4/93

The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death. Since their discovery, the role of AP-1 TFs in cancer development has been extensively analysed. Multiple in vitro and in vivo studies have highlighted the complexity of these TFs, mainly due to their cell-type specific homo- or hetero-dimerization resulting in diverse transcriptional response profiles. However, as a result of the increasing knowledge of the role of AP-1 TFs in disease, these TFs are being recognized as promising therapeutic targets for various malignancies. In this review, we focus on the impact of deregulated expression of AP-1 TFs in CD30-positive lymphomas including Classical Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma.