BOWEL INVOLVEMENT IN PATIENTS WITH SPONDYLOARTHRITIS

• Main Authors: A. E. Karateev, E. A. Galushko
• Format: Article
• Language: Russian
• Published: IMA-PRESS LLC 2015-04-01
• Series: Научно-практическая ревматология
• Subjects: spondyloarthritis; inflammatory bowel diseases; small intestine; large intestine; chronic inflammation; fibrocolonoscopy; video capsule endoscopy; calprotectin; pharmacotherapy; nonsteroidal anti-inflammatory drugs; biological agents
• Online Access: https://rsp.mediar-press.net/rsp/article/view/2075

The pathogenetic  and clinical association between spondyloarthritis  (SpA) and inflammatory bowel diseases (IBD) is well known. Ulcerative colitis and Crohn's disease are more common  in patients with SpA than in general population. In turn, the involvement of the spine and peripheral joints is a typical systemic manifestation  of IBD. But at the same time at least half of patients with SpA have endoscopic and histological signs of chronic inflammation of the small and large intestine mucosa, which are unaccompanied by characteristic  clinical manifestations and cannot considered within a specific nosological entity. The importance  of this pathology has been unknown until the present time. Should asymptomatic  bowel inflammation be considered as a precursor of true IBD, which methods should be used to diagnose bowel involvement and how the presence of this pathology affects the choice of rational pharmacotherapy for SpA? This review analyzes the basic literature data concerning this problem.