Vitamin D Levels in Subjects with Prostate Cancer Compared to Age-Matched Controls

• Main Authors: Subhashini Yaturu, Sonya Zdunek, Barbara Youngberg
• Format: Article
• Language: English
• Published: Hindawi Limited 2012-01-01
• Series: Prostate Cancer
• Online Access: http://dx.doi.org/10.1155/2012/524206

Prostate cancer (PCa) is the second most common cancer in men worldwide and the second leading cause of cancer deaths in men in the United States. Vitamin D is considered to have anticancer properties, currently thought to work mainly through its nuclear receptor or vitamin D receptor. In this retrospective study, we compared vitamin D levels in subjects with PCa with those of age-matched men without PCa. Study subjects included 479 in each group with a mean age of 73 and a mean creatinine of 1.05 and 1.15. Levels of 25 (OH) vitamin D were and in subjects with and without PCa. Levels of 1,25 (OH) vitamin D were and in subjects with and without PCa. In contrast to other studies, we did not find a significant difference in vitamin D levels. Among prostate cancer patients, vitamin D levels correlated positively with age (, ), and were negatively associated with BMI (, ), glucose (, ), HbA1C (, ), and PTH (; ). The data do not show the causal effect of vitamin D levels on PCa.