A Computation using mutually exclusive processing is sufficient to identify specific Hedgehog signalling components

• Main Author: Spencer J Spratt
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2013-12-01
• Series: Frontiers in Genetics
• Subjects: Genetics; Computation; specificity; methods; Method; systems analysis
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00284/full

A system of more than one part can be deciphered by observing differences between the parts. A simple way to do this is by recording something absolute displaying a trait in one part and not in another: in other words, mutually exclusive computation. Conditional directed expression in vivo offers processing in more than one part of the system giving increased computation power for biological systems analysis. Here, I report the consideration of these aspects in the development of an in vivo screening assay that appears sufficient to identify components specific to a system.