Epithelial cells release adenosine to promote local TNF production in response to polarity disruption

Epithelial cells release adenosine to promote local TNF production in response to polarity disruption

Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.

Bibliographic Details
Main Authors: Ingrid Poernbacher, Jean-Paul Vincent
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07114-z
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spelling doaj-5ab7ef674b5e44acbdeb490c8e278ec12021-05-11T09:49:28ZengNature Publishing GroupNature Communications2041-17232018-11-019111010.1038/s41467-018-07114-zEpithelial cells release adenosine to promote local TNF production in response to polarity disruptionIngrid Poernbacher0Jean-Paul Vincent1The Francis Crick InstituteThe Francis Crick InstituteEpithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.https://doi.org/10.1038/s41467-018-07114-z
collection DOAJ
language English
format Article
sources DOAJ
author Ingrid Poernbacher
Jean-Paul Vincent
spellingShingle Ingrid Poernbacher
Jean-Paul Vincent
Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
Nature Communications
author_facet Ingrid Poernbacher
Jean-Paul Vincent
author_sort Ingrid Poernbacher
title Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_short Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_full Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_fullStr Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_full_unstemmed Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_sort epithelial cells release adenosine to promote local tnf production in response to polarity disruption
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.
url https://doi.org/10.1038/s41467-018-07114-z
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AT jeanpaulvincent epithelialcellsreleaseadenosinetopromotelocaltnfproductioninresponsetopolaritydisruption
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